NIN (ninein (GSK3B interacting protein))

Distribution of the microtubule-related protein ninein in developing neurons.

Ninein associates with the centrosome in many cell types, where it recaptures minus-ends of microtubules after their release. In more complex and polarized cells, ninein has also been observed at noncentrosomal locales, where its function is not as well understood. We have found that cultured neurons contain both centrosomal and noncentrosomal ninein, and that the noncentrosomal ninein, typical...

Effects of the ninein-like protein centrosomal protein on breast cancer cell invasion and migration

To investigate the effects of the centrosomal protein, ninein-like protein (Nlp), on the proliferation, invasion and metastasis of MCF-7 breast cancer cells, the present study established green fluorescent protein (GFP)-containing MCF7 plasmids with steady and overexpression of Nlp (MCG7-GFP-N1p) and blank plasmids (MCF7-GFP) using lentiviral transfection technology in MCF7 the breast cancer ce...

Receptor-Interacting Protein Homotypic

Nicotinic augmentation of anti-inflammatory GSK3b signaling

Background Glycogen synthesis kinase 3b (GSK3b) has been shown to be a critical mediator of the intensity and direction of the innate immune system responding to bacterial stimuli. Stimulation of the anti-cholinergic anti-inflammatory system by tobacco alkaloids (nicotine; cotinine) leads to phosphorylation and inactivation of GSK3b and, subsequently, to immune suppression. This presentation wi...

Ninein leads the way in vessel sprouting.

Ninein Leads the Way in Vessel Sprouting Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2008 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.108.17618